Comparative pharmacokinetics of two intravenous administration regimens of tiludronate in healthy adult horses and effects on the bone resorption marker CTX‐1
Identifieur interne : 000221 ( France/Analysis ); précédent : 000220; suivant : 000222Comparative pharmacokinetics of two intravenous administration regimens of tiludronate in healthy adult horses and effects on the bone resorption marker CTX‐1
Auteurs : C. Delguste [Belgique] ; H. Amory [Belgique] ; J. Guyonnet [France] ; D. Thibaud [France] ; P. Garnero [France] ; J. Detilleux [Belgique] ; O. M. Lepage [France] ; M. Doucet [Canada]Source :
- Journal of Veterinary Pharmacology and Therapeutics [ 0140-7783 ] ; 2008-04.
Abstract
Bioavailability and pharmacological effects of tiludronate were compared when administered as an intravenous (i.v.) bolus at a dosage of 0.1 mg/kg body weight (b.w.) once daily for 10 consecutive days (group 1, n = 6) and as a single constant rate infusion (CRI) at a total dose of 1 mg/kg b.w. (group 2, n = 6) in healthy adult horses. Tiludronate and carboxy‐terminal cross‐linking telopeptide of type I collagen (CTX‐1) were measured in plasma and urine. There was no statistically significant difference in area under the curve (AUC) and clearance (Cl) between the two groups. Bioavailability of the CRI was 103% (not significantly different) that of the 10 daily i.v. bolus doses. Cumulative urine tiludronate excretion could not be compared between groups because of poor sensitivity of the assay in urine. Plasma and urine CTX‐1 levels were not different between groups throughout the study. However, interindividual variations were greater in group 1 than in group 2. A significant decrease in CTX‐1 levels was observed in plasma after the first administration in group 1, but not in urine; while in group 2, a significant decrease in CTX‐1 concentrations was observed after treatment in both plasma and urine. In conclusion, both dosage regimens of tiludronate produced similar plasma exposure and pharmacological effects in adult healthy horses.
Url:
DOI: 10.1111/j.1365-2885.2007.00936.x
Affiliations:
- Belgique, Canada, France
- Auvergne-Rhône-Alpes, Province de Liège, Rhône-Alpes, Région wallonne
- Liège, Lyon
- Université de Liège
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002669
- to stream Istex, to step Curation: 002669
- to stream Istex, to step Checkpoint: 000950
- to stream Main, to step Merge: 002540
- to stream Main, to step Curation: 002345
- to stream Main, to step Exploration: 002345
- to stream France, to step Extraction: 000221
Links to Exploration step
ISTEX:3B8106AD6667D5CD43C3EF143016F5A6D203AB69Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative pharmacokinetics of two intravenous administration regimens of tiludronate in healthy adult horses and effects on the bone resorption marker CTX‐1</title><author><name sortKey="Delguste, C" sort="Delguste, C" uniqKey="Delguste C" first="C." last="Delguste">C. Delguste</name></author><author><name sortKey="Amory, H" sort="Amory, H" uniqKey="Amory H" first="H." last="Amory">H. Amory</name></author><author><name sortKey="Guyonnet, J" sort="Guyonnet, J" uniqKey="Guyonnet J" first="J." last="Guyonnet">J. Guyonnet</name></author><author><name sortKey="Thibaud, D" sort="Thibaud, D" uniqKey="Thibaud D" first="D." last="Thibaud">D. Thibaud</name></author><author><name sortKey="Garnero, P" sort="Garnero, P" uniqKey="Garnero P" first="P." last="Garnero">P. Garnero</name></author><author><name sortKey="Detilleux, J" sort="Detilleux, J" uniqKey="Detilleux J" first="J." last="Detilleux">J. Detilleux</name></author><author><name sortKey="Lepage, O M" sort="Lepage, O M" uniqKey="Lepage O" first="O. M." last="Lepage">O. M. Lepage</name></author><author><name sortKey="Doucet, M" sort="Doucet, M" uniqKey="Doucet M" first="M." last="Doucet">M. Doucet</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3B8106AD6667D5CD43C3EF143016F5A6D203AB69</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1365-2885.2007.00936.x</idno><idno type="url">https://api-v5.istex.fr/document/3B8106AD6667D5CD43C3EF143016F5A6D203AB69/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002669</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002669</idno><idno type="wicri:Area/Istex/Curation">002669</idno><idno type="wicri:Area/Istex/Checkpoint">000950</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000950</idno><idno type="wicri:doubleKey">0140-7783:2008:Delguste C:comparative:pharmacokinetics:of</idno><idno type="wicri:Area/Main/Merge">002540</idno><idno type="wicri:Area/Main/Curation">002345</idno><idno type="wicri:Area/Main/Exploration">002345</idno><idno type="wicri:Area/France/Extraction">000221</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Comparative pharmacokinetics of two intravenous administration regimens of tiludronate in healthy adult horses and effects on the bone resorption marker CTX‐1</title><author><name sortKey="Delguste, C" sort="Delguste, C" uniqKey="Delguste C" first="C." last="Delguste">C. Delguste</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liege, Liege</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Amory, H" sort="Amory, H" uniqKey="Amory H" first="H." last="Amory">H. Amory</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liege, Liege</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Guyonnet, J" sort="Guyonnet, J" uniqKey="Guyonnet J" first="J." last="Guyonnet">J. Guyonnet</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>CEVA Santé Animale, Libourne Cedex</wicri:regionArea><wicri:noRegion>Libourne Cedex</wicri:noRegion><wicri:noRegion>Libourne Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Thibaud, D" sort="Thibaud, D" uniqKey="Thibaud D" first="D." last="Thibaud">D. Thibaud</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>CEVA Santé Animale, Libourne Cedex</wicri:regionArea><wicri:noRegion>Libourne Cedex</wicri:noRegion><wicri:noRegion>Libourne Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Garnero, P" sort="Garnero, P" uniqKey="Garnero P" first="P." last="Garnero">P. Garnero</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM research unit 664 and Synarc, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Detilleux, J" sort="Detilleux, J" uniqKey="Detilleux J" first="J." last="Detilleux">J. Detilleux</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liege, Liege</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Lepage, O M" sort="Lepage, O M" uniqKey="Lepage O" first="O. M." last="Lepage">O. M. Lepage</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Département Hippique, Ecole Nationale Vétérinaire de Lyon, Université de Lyon, Marcy L’Etoile</wicri:regionArea><wicri:noRegion>Marcy L’Etoile</wicri:noRegion><wicri:noRegion>Marcy L’Etoile</wicri:noRegion></affiliation></author><author><name sortKey="Doucet, M" sort="Doucet, M" uniqKey="Doucet M" first="M." last="Doucet">M. Doucet</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Département de biomédecine vétérinaire, Faculté de médecine vétérinaire, Université de Montréal, Montréal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Veterinary Pharmacology and Therapeutics</title><idno type="ISSN">0140-7783</idno><idno type="eISSN">1365-2885</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-04">2008-04</date><biblScope unit="volume">31</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="108">108</biblScope><biblScope unit="page" to="116">116</biblScope></imprint><idno type="ISSN">0140-7783</idno></series><idno type="istex">3B8106AD6667D5CD43C3EF143016F5A6D203AB69</idno><idno type="DOI">10.1111/j.1365-2885.2007.00936.x</idno><idno type="ArticleID">JVP936</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0140-7783</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bioavailability and pharmacological effects of tiludronate were compared when administered as an intravenous (i.v.) bolus at a dosage of 0.1 mg/kg body weight (b.w.) once daily for 10 consecutive days (group 1, n = 6) and as a single constant rate infusion (CRI) at a total dose of 1 mg/kg b.w. (group 2, n = 6) in healthy adult horses. Tiludronate and carboxy‐terminal cross‐linking telopeptide of type I collagen (CTX‐1) were measured in plasma and urine. There was no statistically significant difference in area under the curve (AUC) and clearance (Cl) between the two groups. Bioavailability of the CRI was 103% (not significantly different) that of the 10 daily i.v. bolus doses. Cumulative urine tiludronate excretion could not be compared between groups because of poor sensitivity of the assay in urine. Plasma and urine CTX‐1 levels were not different between groups throughout the study. However, interindividual variations were greater in group 1 than in group 2. A significant decrease in CTX‐1 levels was observed in plasma after the first administration in group 1, but not in urine; while in group 2, a significant decrease in CTX‐1 concentrations was observed after treatment in both plasma and urine. In conclusion, both dosage regimens of tiludronate produced similar plasma exposure and pharmacological effects in adult healthy horses.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Canada</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Province de Liège</li><li>Rhône-Alpes</li><li>Région wallonne</li></region><settlement><li>Liège</li><li>Lyon</li></settlement><orgName><li>Université de Liège</li></orgName></list><tree><country name="Belgique"><region name="Région wallonne"><name sortKey="Delguste, C" sort="Delguste, C" uniqKey="Delguste C" first="C." last="Delguste">C. Delguste</name></region><name sortKey="Amory, H" sort="Amory, H" uniqKey="Amory H" first="H." last="Amory">H. Amory</name><name sortKey="Detilleux, J" sort="Detilleux, J" uniqKey="Detilleux J" first="J." last="Detilleux">J. Detilleux</name></country><country name="France"><noRegion><name sortKey="Guyonnet, J" sort="Guyonnet, J" uniqKey="Guyonnet J" first="J." last="Guyonnet">J. Guyonnet</name></noRegion><name sortKey="Garnero, P" sort="Garnero, P" uniqKey="Garnero P" first="P." last="Garnero">P. Garnero</name><name sortKey="Lepage, O M" sort="Lepage, O M" uniqKey="Lepage O" first="O. M." last="Lepage">O. M. Lepage</name><name sortKey="Thibaud, D" sort="Thibaud, D" uniqKey="Thibaud D" first="D." last="Thibaud">D. Thibaud</name></country><country name="Canada"><noRegion><name sortKey="Doucet, M" sort="Doucet, M" uniqKey="Doucet M" first="M." last="Doucet">M. Doucet</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000221 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000221 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:3B8106AD6667D5CD43C3EF143016F5A6D203AB69
|texte= Comparative pharmacokinetics of two intravenous administration regimens of tiludronate in healthy adult horses and effects on the bone resorption marker CTX‐1
}}
| This area was generated with Dilib version V0.6.29. |  |